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SYDNEY, March 7, 2023 (Newswire.com)
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Parnell Pharmaceuticals Holdings Ltd (OTC: PARNF), a fully integrated, commercial-stage pharmaceutical company focused on developing, manufacturing and marketing innovative animal health solutions, provides notice of its Annual General Meeting to be held Thursday, April 6th 2023 at 8:30 a.m. (Australian Eastern Standard Time).
NOTICE OF ANNUAL GENERAL MEETING AND EXPLANATORY MEMORANDUM
Notice is given that the Annual General Meeting of shareholders of Parnell Pharmaceuticals Holdings Ltd (Company) will be held on:
Thursday, April April 6th 2023 at 8:30 a.m. (Australian Eastern Standard Time)
The meeting is to be held in person at the Company’s headquarters: First Floor, Unit 4, 476 Gardeners Road, Alexandria NSW, 2015, Australia
For a link to the full Notice of Annual General Meeting and Explanatory Memorandum please click:
https://cdn.newswire.com/files/x/06/4e/973f63370a45ad06e2bcb4d2b55f.pdf
_________________________________
28 February 2023
Dear Shareholder,
On behalf of the Board of Directors of Parnell Pharmaceuticals Holdings Limited (ACN 137 904 413) (Company), I invite you to join us at our Annual General Meeting (AGM), which has been scheduled as follows:
Date: Thursday, April 6th 2022 (AEST)
Time: 8:30 a.m. (AEST)
Venue: Held by physical attendance at: First Floor, Unit 4 Century Estate, 476 Gardeners Road, Alexandria, NSW, 2015
Outline of the business of the GM
At this GM, we will consider whether to approve the buying back of shares in the Company (“Shares”) owned by Mr Robert Joseph and Mrs Kate Joseph, pursuant to a Settlement and Mutual Release Agreement recently made by the Company with Mr and Mrs Joseph.
Details of this business are contained in the enclosed Notice of GM and Explanatory Memorandum.
Voting at the GM or by proxy
A proxy form accompanies the enclosed Notice of GM. If you wish to attend the GM in person, please bring a copy of the proxy form with you. Registration will be available from [time] (AEST). If you are unable to attend in person, I encourage you to appoint a proxy to vote on the resolutions contained in the Notice of GM on your behalf, by completing and returning the enclosed proxy form. Details of how to submit the proxy form are included with the form.
If you have any difficulties placing your vote via proxy please do not hesitate to contact Brad McCarthy at [email protected] or call +612 9667 4411.
On behalf of all of the Directors, we look forward to hearing from you at the AGM.
Yours sincerely,
Alan Bell
Chairman
Related Files
Parnell Notice of General Meeting and Ex Mem (Buy-Back) – Final (Apr’23).pdf
Original Source:
Parnell Pharmaceuticals Gives Notice of Annual General Meeting and Explanatory Memorandum
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Switch Takes ‘Accessible Luxury’ to a New Level by Launching Luxury Handbags as Part of Its Core Membership
LOS ANGELES, March 7, 2023 (Newswire.com)
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Luxury accessory rental startup Switch has launched handbags as part of its low-priced Core membership tier. Until now, Switch’s Core membership exclusively featured jewelry. The expansion means that members will be able to borrow designer handbags by luxury fashion brands including Chanel, Louis Vuitton, and Christian Dior for $45 per month.
While other luxury rental services have emerged in recent years, none have offered access to luxury handbags at such a low price point. The move highlights Switch’s ambition to make luxury more attainable.
“Switch is all about challenging traditional notions of luxury,” said Adriel Darvish, Co-Founder and CEO of Switch. “By adding handbags to our Core membership, our goal is to make the luxury experience, which has traditionally been hyper-exclusive and intimidating, more inclusive and fun.”
The move follows the wildly successful rollout of its higher-end tier Switch Select at the end of last year. Select features jewelry and handbags with an average retail value of $4,000, which members can borrow for $195 per month. Because of the continued high demand, aspiring Select members must sign up for a waitlist, from which members are admitted on a rolling basis.
“The success of our Select membership has highlighted the immense demand for luxury handbags,” added Switch President and co-founder Liana Kadisha Cohn. “Once we saw that customer interest, we quickly responded by making it a part of our Core offering as well.”
All Switch plans allow members to borrow their pieces for as long as they want, exchange them as often as they want, and purchase their favorites at a discounted price.
ABOUT SWITCH
Switch is on a mission to revolutionize luxury by providing unparalleled access to designer accessories. For a monthly fee starting at $45/month, members can borrow from an ever-expanding trove of designer jewelry and handbags and exchange it any time, as often as they wish. Members also earn credit each month, which they can use towards purchasing their favorites at a discount. Switch is the grown-up’s dress-up trunk — a place for play, discovery, and owning your style (albeit not literally).
Contact Information:
Natallie Mashian
Head of PR and Partnerships
(310) 666-0641
Original Source:
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Biopharmaceutical research company specializing in cannabis- and plant-inspired medicines shares strategic plan for 2023 and key developments from 2022
LAS VEGAS, March 7, 2023 (Newswire.com)
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Gb Sciences, Inc. (OTCQB:GBLX), a leading cannabis- and plant-inspired biopharmaceutical research and development company, issued a letter to shareholders today from President, Chief Science Officer, and Director Dr. Andrea Small-Howard and Chairman and CEO John Poss summarizing key developments from 2022 and providing strategic plans for 2023. Full text of the shareholder letter follows.
A MESSAGE FROM BOTH THE PRESIDENT AND THE CHAIRMAN OF GB SCIENCES, INC.
To Our Shareholders:
In 2022, Gb Sciences achieved significant milestones advancing our plant-inspired drug development pipeline for the treatment of a broad spectrum of critical and prevalent diseases, which supports the value of PhAROS™, our proprietary AI-enabled Drug Discovery Platform. Gb Sciences is entering 2023 with very good reason for excitement and optimism for our shareholders and for the potential to develop first-in-class drugs to treat serious disorders such as: Parkinson’s Disease, Advanced Heart Disease, Chronic Pain, Inflammation, Anxiety and Depression. In addition, our intellectual property portfolio currently contains six issued U.S. and four issued foreign patents, as well as 15 U.S. and 49 foreign patent-pending applications that cover our novel AI-enabled drug discovery platform and proprietary therapies for more than 65 different disorders.
Recognizing the value of our PhAROS™ Drug Discovery Platform for expediting our novel plant-inspired drug pipeline, we also realize that PhAROS™ has the potential to be of high value to other drug development biotech and pharmaceutical companies. With its data analytics and machine learning capabilities providing a breakthrough in drug discovery, our PhAROS™ Drug Discovery Platform greatly reduces the time and money required to discover and bring novel formulations to market. Therefore, in addition to developing our own biopharma pipeline, we plan to monetize PhAROS™ by pursuing potential licensing and/or partnerships with other drug developers that offer the potential to generate substantial, recurring, high-margin revenues to Gb Sciences.
While other drug developers pursue conventional drug pathways, Gb Sciences is developing novel Minimal Essential Mixtures derived from the active ingredients found within traditional plant-based medicines that are still commonly used across the world. Traditional medicines that are mostly plant based have been used for centuries and are composed of all the ingredients for specific plants which can number in the hundreds or even thousands. Gb Sciences uses our novel PhAROS™ Drug Discovery Platform to determine which three ingredients of the hundreds of ingredients found in each plant are the most effective and with the fewest adverse side effects.
In 2022, Gb Sciences has successfully prepared our lead program in Parkinson’s disease for a first-in-human trial through the following essential steps: a) creating clinical prototypes by combining our proprietary Parkinson’s formulas with a convenient oral delivery system; b) performing a dose response study in rodents to establish the correct range of active ingredients for our first-in-human trial; c) performing necessary ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicology) tests on the clinical prototypes; and d) selecting a Contract Research Organization (CRO) to prepare an Investigational New Drug (IND) application to the U.S. FDA to begin our first-in-human trial.
Working with Catalent Pharma in 2022, Gb Sciences has successfully prepared the clinical prototypes of our proprietary cannabinoid-based formulations for Parkinson’s disease in Catalent Pharma’s proprietary Zydis® delivery system. Catalent Pharma’s Zydis® delivery system is an Orally Disintegrating Tablet format that should be ideal for delivering our cannabinoid-ratio controlled formulations to Parkinson’s patients. More than 50% of Parkinson’s patients have trouble swallowing, but the Zydis® format delivers the active ingredients into the mouth by dispersion without needing water or the ability to swallow.
In February of 2023, the University of Lethbridge has successfully completed our dose response study in rodents, which helps us to establish the correct dosing of our cannabinoid-containing Parkinson’s formulations in our first-in-human trial. The results of this important study will be delivered to Gb Sciences from the University of Lethbridge within the next six weeks.
Prior to filing our IND application for our first-in-human trial on our Parkinson’s formulations, Gb Sciences must conduct ADMET testing on the clinical prototypes being formulated for us by Catalent Pharma. Gb Sciences has selected Labcorp Drug Development, formerly Covance, to perform our IND-enabling studies due to their expertise and testing locations in the United Kingdom near to where the ODT tablets are being manufactured by Catalent Pharma.
In the IND application for our Parkinson’s disease therapeutics, the ADMET testing data from Labcorp will be combined with the Chemistry Manufacturing and Controls (CMC) data prepared by Catalent Pharma and our proof-of-concept data from the National Research Council (NRC) of Canada. In the near future, we expect to announce the selection of the Contract Research Organization that will write the IND application and run the first-in-human trials for our novel treatment for the motor symptoms of Parkinson’s disease.
Gb Sciences has four other promising late-preclinical stage programs, including our COVID-related cytokine release syndrome (COVID-CRS) formulations and our time-released oral nanoparticle formulations for chronic pain. We have achieved preclinical proof-of-concept for our COVID-CRS formulas in studies performed by Michigan State University. Our chronic pain formulations are being validated in animal trials at the National Research Council of Canada. Recently, we have announced that our kava-inspired formulas for anxiety have achieved animal proof-of-concept. Gb Sciences is now preparing its non-psychedelic, kava-based anxiety formulations to treat the growing global need for anxiety and depression relief.
In closing, we would like to thank those shareholders who have supported our company this year and in past years. Our goal remains to produce maximum shareholder value while also providing innovative new therapeutic options for patients that need them.
Sincerely,
Dr. Andrea Small-Howard
President, CSO & Director
Gb Sciences, Inc.
John Poss
Chairman & CEO
Gb Sciences, Inc.
To learn more about Gb Sciences, visit www.gbsciences.com.
About Gb Sciences and GbS Global Biopharma
Gb Sciences, Inc. is a plant-inspired, biopharmaceutical research and development company creating patented, disease-targeted formulations of cannabis- and other plant-inspired therapeutic mixtures for the prescription drug market through its Canadian subsidiary GbS Global Biopharma, Inc. The “plant-inspired” active ingredients in its therapeutic mixtures are synthetic homologues identical to the original plant compounds but produced under current Good Manufacturing Practices. Gb Sciences’ intellectual property portfolio contains six issued U.S. and four issued foreign patents, as well as 15 U.S. and 49 foreign patent-pending applications. In its drug development pipeline, Gb Sciences has five preclinical phase product development programs. Gb Sciences’ lead program for Parkinson’s disease is being prepared for a first-in-human clinical trial. Gb Sciences’ formulations for chronic pain, anxiety and depression are currently in preclinical animal studies with researchers at the National Research Council of Canada (NRC). The company also received positive preclinical proof-of-concept data supporting its complex mixtures for the treatment of Cytokine Release Syndrome, and its lead candidates will be optimized based on late-stage preclinical studies at Michigan State University. Gb Sciences’ productive research and development network includes distinguished universities, hospitals, and Contract Research Organizations. To learn more, visit www.gbsciences.com.
Forward-Looking Statements
This press release may contain statements relating to future results or events, which are forward-looking statements. Words such as “expects,” “intends,” “plans,” “may,” “could,” “should,” “anticipates,” “likely,” “believes” and words of similar import may identify forward-looking statements. These statements are not historical facts, but instead represent only the Company’s belief regarding future events, many of which, by their nature, are inherently uncertain and outside of the Company’s control. It is possible that the Company’s actual results and financial condition may differ, possibly materially, from the anticipated results and financial condition indicated in these forward-looking statements. Further, information concerning the Company and its business, including factors that potentially could materially affect the Company’s business and financial and other results, are contained in the Company’s filings with the Securities and Exchange Commission, available at www.sec.gov. All forward-looking statements included in this press release are made only as of the date of this press release, and we do not undertake any obligation to publicly update or correct any forward-looking statements to reflect events or circumstances that subsequently occur or of which we hereafter become aware.
Contact Information:
Alexis Quintal
Original Source:
Successful 2022 Milestones Support Value of Gb Sciences’ AI-Enabled Drug Discovery Platform
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